GI - Intra-abdominal Abscess

Peritonitis or Intra-abdominal Abscess (secondary to bowel or appendicular perforation)

Enteric gram-negative bacilli, Bacteroides spp, Enterococcus spp, Pseudomonas aeruginosa

Ceftriaxone 75mg/kg/dose IV q24h (max 2000mg/dose)

AND

Metronidazole 30mg/kg/day PO/IV div q8h (max 500mg/dose)

If Healthcare Associated (recently hospitalized, underlying medical conditions associated w/pseudomonal colonization/known colonization):

Piperacillin-tazobactam 400mg/kg/day (based on piperacillin component) IV div q6h (max 4000mg/dose of Piperacillin)¹

Empiric Therapy & Alternative Regimens

Consult Infectious Diseases.

Consult General Surgery for evaluation of need for washout or drainage.

Length of Therapy:

Discuss with Infectious Diseases, will depend on clinical course and source control.