Drug-susceptible Pulmonary Tuberculosis:

Rifampin 20mg/kg/day PO div q24h (max 600mg) for 6 months

AND

Isoniazid 10mg/kg/day PO div q24h (max 300mg) for 6 months

AND

Pyrazinamide 30-40mg/kg/day PO div q24h (max 2000mg) for 2 months

AND

Ethambutol 20mg/kg/day PO div q24h (max 2500mg/dose) for 2 months¹

 

Latent Tuberculosis:

Isoniazid 10mg/kg/day PO div q24h (max 300mg) for 6 months

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OR

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 Rifampin 20mg/kg/day PO div q24h (max 600mg) for 4 months

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OR

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Isoniazid 10mg/kg/day PO div q24h AND

Rifapentine once weekly for 3 months:

• 10 to 14 kg: 300 mg/dose once weekly

• >14 to 25 kg: 450 mg/dose once weekly

• >25 to 32 kg: 600 mg/dose once weekly

• >32 to 50 kg: 750 mg/dose once weekly

• >50 kg: 900 mg/dose once weekly²